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Question:

A colourblind man marries a daughter of a colourblind father. What will be the result in the next generation?

All sons will be colourblind

Half of the sons will be colourblind

There will be no daughter colourblind

All daughter will be colourblind

Solution:

Colourblindness is an X-linked recessive disorder and follows criss-cross inheritance.
A colourblind man (XcY) and the daughter of a colourblind father (XcX) will produce the following offspring:

Possible gametes from the colourblind man (XcY): Xc and Y
Possible gametes from the daughter of a colourblind father (XcX): Xc and X

Punnett Square:

Xc X
Xc XcXc XcX
Y XcY XY

This results in:

  • XcXc: Colourblind daughter (1/4 probability)
  • XcX: Carrier daughter (1/4 probability)
  • XcY: Colourblind son (1/4 probability)
  • XY: Normal son (1/4 probability)

Hence, half of the sons will be colourblind. So, the correct answer is B.