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Question:

A person suffering from a disease caused by Plasmodium experiences recurring chill and fever at the time when:

  • The microgametocytes and megagametocytes are being destroyed by the WBCs.
  • The trophozoites reach maximum growth and give out certain toxins.
  • The sporozoites released from RBCs are being rapidly killed and broken down inside spleen.
  • The parasite after its rapid multiplication inside RBCs ruptures them, releasing the stage to enter fresh RBCs.

The microgametocytes and megagametocytes are being destroyed by the WBCs.

The sporozoites released from RBCs are being rapidly killed and broken down inside spleen.

The trophozoites reach maximum growth and give out certain toxins.

The parasite after its rapid multiplicaiton inside RBCs ruptures them, releasing the stage to enter fresh RBCs.

Solution:

The malarial paroxysm usually lasts 4-8 hours and begins with a sudden onset of chills in which the patient experiences an intense feeling of cold and elevated temperature. This is referred to as the cold stage and is characterized by vigorous shivering. It is caused by the rupture of the infected erythrocytes and the release of merozoites which further affects the new RBC. So, the correct answer is option D.