Anaphase Promoting Complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur?

Anaphase promoting complex helps in the transition of the chromosome from metaphase to anaphase. The APC attaches to the chromosomes aligned at the equator during metaphase and allows the segregation of the chromatids. So, the correct answer is option D.