Eduprobe
Question:
In the following reaction, carbonyl compound + MeOH + HCl ⇌ acetal. Rate of the reaction is the highest for:
acetone as substrate and methanol in stoichiometric amount
propanal as substrate and methanol in stoichiometric amount
acetone as substrate and methanol in excess
propanal as substrate and methanol in excess
Solution:
Correct option is D. propanal as substrate and methanol in excess. Acetone as substrate is less reactive than propanal towards nucleophilic addition.