Trace the life-cycle of malarial parasite in the human body when bitten by an infected female Anopheles.

Malaria is caused by the biting of a female Anopheles mosquito to a healthy human being, releasing Plasmodium, which lives in an infectious form (sporozoite).

1. First, it undergoes asexual reproduction when the parasites burst the liver cells by multiplying themselves, and are released into the blood.
2. Again it bursts the RBC by entering inside and multiplying by means of asexual reproduction.
3. Along with the bursting of RBC, a toxic element called haemozoin is released that causes chills in the body of the human being.
4. Gametocytes multiply, forming from the sporozoites that multiply sexually.
5. Gametocytes are introduced into the mosquito when the female Anopheles mosquito bites the diseased person.
6. Gametocytes again form sporozoites by fertilizing inside the intestine of the mosquito.
7. These sporozoites are stored in the salivary glands of the mosquito and are released when a healthy person is bitten by this mosquito.