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Question:

Which of the following reactions needs catalysis by a decarboxylase enzyme?

Fumaric acid to malic acid

Conversion of citric acid to cis-aconitic acid

Malic acid to oxaloacetic acid

Oxalosuccinic acid to α-ketoglutaric acid

Solution:

Oxalosuccinate is decarboxylated to form α-ketoglutarate through the enzyme decarboxylase. It is one of the steps involved in the Krebs cycle. It releases one molecule of CO2. Oxalosuccinate + Decarboxylase → Mg2+ + α-ketoglutarate + CO2